In this paper, the effect of operating conditions on the cathode of a fuel cell is made of plastic on its performance. For this purpose, two-dimensional and two-phase simulation of a fuel cell unit including gas ducts, gas diffusion layers and the cathode and the anode catalyst and the membrane area was conducted. The governing equations of the fuel cell using multi-phase model caraway and with regard to the single zone model was solved using coding and concentration VaknshGr components resulting in cell polarization curves were obtained. The effect of voltage, pressure, temperature, speed and relative humidity of the cathode on the concentration of oxygen and water as well as cell function studied and evaluated. The results show that by increasing the operating temperature of the cell, fuel cell performance improves. With increasing speed, pressure and relative humidity of the gas stream entering the channel, fuel cell efficiency increases. In order to validate the results obtained, the yield curve of single-phase and two-phase simulation compared with experimental results and good agreement was observed between them.